… The role of RNA oxidation in ammonia neurotoxicity and HE … The ammonia-induced RONS
formation activates a number … , ammonia- and hypoosmolarity-induced nitrosative stress in …

… of oxidative/nitrosative stress is closely related to the pathogenesis of cerebral ammonia …
The exact mechanism of ammonia neurotoxicity is not completely understood. In pediatric …

… Increased oxidative stress is present in several chronic … associated with inflammation,
neurotoxicity, and oxidative stress. The … osmotic stress and cerebral oxidative/nitrosative stress …

… Excitotoxicity could cause a severe elevation in the cytoplasmic Ca 2+ ion, significant
oxidative/nitrosative stress, and mitochondrial dysfunction in neurons and astrocytes. [ 4, 21, 22 ] …

… -induced oxidative stress plays a critical role in its neurotoxicity. Please refer to “Section 40.3”
for more information about the role of oxidative stress in NH 4 + -induced neurotoxicity and …

… and ammonia. … induced neurotoxicity via attenuation of neurochemical, ATPase changes,
and inhibition of acetylcholinesterase activity, ammonia release and oxidative/nitrosative stress …

… alterations, the definitive relationship between ammonia and the aged brain is not yet … of
ammonia in the aged brain. On the basis of this, we hypothesize that the modulation of ammonia …

… of ammonia, which is neurotoxic [132]. However, the use of such amino acids as a compensatory
energy supply is likely not a long-term solution. Amino acid levels can become quickly …

… of ammonia neurotoxicity include overlapping processes involving oxidative–nitrosative
stress … Thus, we investigated whether markers of oxidative-nitrosative stress and inflammatory …

… This leads to an accumulation of neurotoxic substances, chief among them ammonia and …
Ammonia and toxin accumulation leads to astrocyte swelling, oxidative and nitrosative stress, …